Safety of Prevagen
Prevagen contains apoaequorin which has been shown to help improve memory in clinical studies. Apoaequorin is a protein that was originally discovered in jellyfish and now produced at our cGMP compliant and NSF certified facility in Wisconsin.
Safety studies conducted on the toxicity and allergenicity of apoaequorin show that apoaequorin is safe. In rats following subchronic administration of amounts up to 666.7mg per kilogram of body weight per day Apoaequorin preparation did not result in any mortality.1 This was the maximum dosage that was tested. Researchers concluded,
“The administration of the Apoaequorin preparation did not result in any mortality. There were no further clinical or opthalmological signs, body weight, body weight gain, food consumption, food efficiency, clinical pathology, or histopathological changes attributable to administration of Apoaequorin.”2
Dosing in the study was the equivalent of 4,000 times the recommended daily amount of Prevagen 10mg and 2,000 times the recommended daily amount of Prevagen Extra Strength 20mg. In addition, apoaequorin achieved self-affirmed GRAS status (generally recognized as safe) after an independent panel of expert scientists concluded that apoaequorin is safe for use in food products.
1. Marone, P.A., Bauter, M., Hofman-Hüther, H., and Moran, D. (2013). Safety assessment of Apoaequorin, a protein preparation: Subchronic toxicity study in rats. Food and Chemical Toxicology 57.
2. Marone, P.A., Bauter, M., Hofman-Hüther, H., and Moran, D. (2013). Toxicologic Evaluation of the Calcium Binding Protein Apoaequorin. Poster presented at the Society of Toxicology Annual Meeting, San Antonio, Texas.